Single prolonged stress: toward an animal model of posttraumatic stress disorder

Toward an animal model of posttraumatic stress disorder.

Posttraumatic stress disorder (PTSD) belongs to the most frequent anxiety disorders. Despite a broad body of evidence concerning neurobiological correlates of this illness, the pathomechanisms of PTSD are still poorly understood. This illustrates the need to establish animal models of this disorder. Recently, PTSD model has become a somewhat fashionable term used in animal studies for almost ev...

Single-prolonged stress induces apoptosis in dorsal raphe nucleus in the rat model of posttraumatic stress disorder

INTRODUCTION Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops after exposure to a life-threatening traumatic experience. Meta-analyses of the brainstem showed that midsagittal area of the pons was significantly reduced in patients with PTSD, suggesting a potential apoptosis in dorsal raphe nucleus after single-prolonged stress (SPS). The aim of this study is to investi...

Posttraumatic Stress Disorder: An Immunological Disorder?

Patients with posttraumatic stress disorder (PTSD) exhibit an increased state of inflammation. Various animal models for PTSD have shown some of the same immune imbalances as have been shown in human subjects with PTSD, and some of these studies are discussed in this review. However, animal studies can only indirectly implicate immune involvement in PTSD in humans. This review of mainly studies...

Prolonged exposure and psychodynamic treatment for posttraumatic stress disorder.

Exercise Maintains Dendritic Complexity in an Animal Model of Posttraumatic Stress Disorder.

INTRODUCTION This study examined the effect of endurance exercise on dendritic arborization in the dentate gyrus subregion in rodents exposed to a predator scent stress (PSS). METHODS Sprague-Dawley rats were randomly assigned to one of four treatment groups. In two of the groups, rats were unexposed to PSS but either remained sedentary (SED + UNEXP) or were exercised (EX + UNEXP). In the oth...